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Implementation of NPBT in chicory for bioactive terpenes
Root chicory is grown for inulin, but it also produces a number of compounds in its latex. These compounds belong to the class of terpenes and the most abundant of these are sesquiterpene lactones (STLs), which have a potential as antimicrobial and anticancer bioactives.
However these compounds may interfere with the extraction of inulin. Therefore in CHIC we have the following twofold objectives:
- To understand how these terpenes accumulate in the latex, how laticifers (the specialized cells that accumulate latex) develop and characterize the bioactivity of compounds that are present in the latex. With this knowledge at hand, chicory could be developed as a biofactory for the production of valuable sesquiterpene lactones. To reduce the impact of latex in the extraction of inulin, we aim to decrease the number of laticifer cells in the tap root.
- Our data shows that the early steps of STLs biosynthesis take place outside of the laticifer cells and STLs accumulate inside of laticifers by transportation mediated process. Based on this information, candidate genes for the development of laticifers and biosynthesis of STLs have been selected. Preliminary bioactivity assays indicate the presence of anti-biofilm activities.
Furthermore, candidate genes involved in the accumulation of costunolide and parthenolide have been identified to generate modified plants with higher amount of parthenolide, an anticancer compound.
More news about this project:
What are New Plant Breeding Techniques (NPBTs)?
New Plant Breeding Techniques (NPBTs) are innovative tools that enable plant breeders to develop novel plant varieties that may provide solutions for environmental and food quality as well as food supply challenges.
Are you wondering why this European project is called CHIC?
CHIC is the Chicory Innovation Consortium. Its objective is to implement New Plant Breeding Techniques (NPBTs) in chicory in order to establish it as a multipurpose crop for the production of health-related products.
Postdoctoral position available at Lille University
A postdoctoral position is available in the group Evolutionary genomics of plant mating systems of the Evolution, Ecology, and Paleontology laboratory of the Lille University, directed by Prof Dr Xavier Vekemans.