NEWS | Chic >
Assessing the intestinal permeability and anti-inflammatory potential of sesquiterpene lactones from chicory
Chicory is a main dietary source of sesquiterpene lactones (SLs), which have underexplored bioactive potential. It has recently gained popularity due to large quantities of health promoting compounds in its roots, including inulin and SLs.
We are pleased to announce the recently accepted scientific publication about chicory from one of our partners, Claudia Nunes dos Santos from iBET entitled, “Assessing the Intestinal Permeability and Anti-Inflammatory Potential of Sesquiterpene Lactones from Chicory”, published in Nutrients (https://doi.org/10.3390/nu12113547).
In the study, researchers have assessed the capacity of SLs to permeate the intestinal barrier to become physiologically available, using in silico predictions and in vitro studies with the well-established cell model of the human intestinal mucosa (differentiated Caco-2 cells). Researchers also evaluated the potential of SLs to modulate inflammatory responses through modulation of the nuclear factor of activated T-cells (NFAT) pathway, using a yeast reporter system. The study revealed Lactucopicrin as the most permeable chicory SL in the intestinal barrier model but had low anti-inflammatory potential. Accordingly, 11β,13-dihydrolactucin SL showed with the highest anti-inflammatory potential, which inhibited up to 54% of Calcineurin-responsive zinc finger (Crz1) activation, concomitantly with the impairment of the nuclear accumulation of Crz1, the yeast orthologue of human NFAT.
More news about this project:
Researchers have used new breeding techniques to develop a chicory variety that no longer contains bitter compounds. The research consortium published their results in the Plant Biotechnology Journal.
Artists Anna Dumitriu and Alex May will discuss their project “Biotechnology from the Blue Flower” with a panel of experts from the EU Horizon H2020 CHIC project. Chicory is believed to have inspired the notion of the Blue Flower in German Romanticism – a central symbol of the movement.
Join us for this fascinating online panel discussion and cooking workshop. “Let’s eat CHICque. Gourmet Aftertastes” opens up the unique art, science and culinary potentials of alternative healthy ingredients in Chicory (Cichorium intybus).